A Protein-Protein Interaction Network of Chronic Myelocytic Leukemia and Pathway Prediction of Molecular Complexes

Chronic myelogenous leukemia (CML) is a kind of chronic myeloproliferative disorders of primitive pluripotent hematopoietic stem cells. The special cytogenetic features of Chronic myelogenous leukemia cells is Philadelphia chromosome t (9; 22) (q34; q11). The proto-oncogene c-ABL in the long arm of Chromosome 9 translocates to the breakpoint cluster pool (BCR) of the long arm of chromosome 22 , formating fusion gene BCR-ABL. Which encodes a protein having a strong activity of tyrosinase. The tyrosine kinase pathway can be phosphorylated by a variety of genes such as RAS, myc, c-CBL, phthalocyanine inositol phospholipid 3 ‘kinase, and NF-kB. Downstream of tyrosinase stimulation is the expression of oncogenes including c-fos, c-jun, etc. which stimulate cell non-growth factor-dependent proliferation and block apoptosis eventually leading to uncontrolled cell proliferation. BCR-ABL gene is considered as the molecular basis of the pathogenesis of CML and as an effective indicator diagnosis, efficacy, prognosis. The gene targeted drugs for the treatment of leukemia has